ea0014p569 | (1) | ECE2007
Giordano Roberta
, Berardelli Rita
, Picu Andreea
, Balbo Marcella
, Bonelli Lorenza
, Barberis Anna
, Ghigo Ezio
, Arvat Emanuela
HPA response to glucocorticoids (GCs) feedback is usually tested by dexamethasone (DEX), a synthetic GC; it poorly crosses BBB and preferentially activates pituitaric glucocorticoid receptor (GR), with a binding potency to GR 7 fold higher and an anti-inflammatory potency about 35 fold higher than cortisol. Cortisol, which easily penetrates into CNS, could better evaluate the GC feedback by acting also at supra-pituitary level. We studied the effects of 150 min infusion of hyd...